Oligodepsipeptide (nano)carriers: Computational design and analysis of enhanced drug loading

Rational Design of Nanocarriers with Enhanced Carrier-drug Interaction for Improved Cancer Therapy

Design and bioinformatics analysis of novel biomimetic peptides as nanocarriers for gene transfer

Objective(s): The introduction of nucleic acids into cells for therapeutic objectives is significantly hindered by the size and charge of these molecules and therefore requires efficient vectors that assist cellular uptake. For several years great efforts have been devoted to the study of development of recombinant vectors based on biological domains with potential applications in gene therapy....

Design of the optimal magnetic field in application of functionalized CNT-based drug delivery toward the cell membrane: Computational Analysis

Recently, Carbon Nano (CN) structures are widely used in medical applications, especially the detection and treatment of cancer disease. Among various types of CNs, Carbone Nano Tubes (CNTs) attracted many researchers' attention to consider them toward clinical application. Regarding the intrinsic structure of CNTs, they can be used widely in drug delivery applications. Functionalized CNTs and ...

Computational Drug Design and Small Molecule Library Design Computational Drug Design

Final Paper Computational Drug Design and Small Molecule Library Design Computational Drug Design In the past decade, significant investments in drug development have not translated into a parallel growth in new drugs [1]. Increasing knowledge and understanding of disease have expanded the number of therapeutic protein targets. However, few drug candidates targeting them reach the market as man...

Merging high doxorubicin loading with pronounced magnetic response and bio-repellent properties in hybrid drug nanocarriers.

Hybrid magnetic drug nanocarriers are prepared via a self-assembly process of poly(methacrylic acid)-graft-poly(ethyleneglycol methacrylate) (p(MAA-g-EGMA)) on growing iron oxide nanocrystallites. The nanocarriers successfully merge together bio-repellent properties, pronounced magnetic response, and high loading capacity for the potent anticancer drug doxorubicin (adriamicin), in a manner not ...